Water → HCID 10460715、化合物

HRID 982715ノート

反応式

HRID 982715 の反応式
C(N(C(C)C)CC)(C)C.[Cl:10][C:11]1[CH:39]=[CH:38][C:14]([CH2:15][NH:16][C:17]([C:19]2[C:20](=[O:37])[C:21]3[S:34][C:33]([CH2:35]Cl)=[CH:32][C:22]=3[N:23]([CH2:25][C:26]([N:28]([O:30][CH3:31])[CH3:29])=[O:27])[CH:24]=2)=[O:18])=[CH:13][CH:12]=1.[O:40]1[CH:44]=[CH:43][CH:42]=[C:41]1[CH:45]([OH:49])[CH2:46][NH:47][CH3:48].O>CN(C=O)C>[Cl:10][C:11]1[CH:39]=[CH:38][C:14]([CH2:15][NH:16][C:17]([C:19]2[C:20](=[O:37])[C:21]3[S:34][C:33]([CH2:35][N:47]([CH2:46][CH:45]([C:41]4[O:40][CH:44]=[CH:43][CH:42]=4)[OH:49])[CH3:48])=[CH:32][C:22]=3[N:23]([CH2:25][C:26]([N:28]([O:30][CH3:31])[CH3:29])=[O:27])[CH:24]=2)=[O:18])=[CH:13][CH:12]=1

参加物

6

反応物 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 11320981Rac-1-(2-furyl)-2-(methylamino)ethanolHCID 22563219HCID 22563219、化合物

生成物 1

HCID 10460715HCID 10460715、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

Diisopropylethylamine (34 μL, 0.19 mmol) was added to a mixture of N-(4-chlorobenzyl)-2-(chloromethyl)-4-{2-[methoxy(methyl)amino]-2-oxoethyl}-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide (60 mg, 0.13 mmol) and 1-(2-furyl)-2-(methylamino)ethanol (27 mg, 0.19 mmol) in DMF (2.0 mL). The mixture was shaken at 60° C. for 3 hrs. The reaction was cooled to room temperature before the addition of water (5 mL). The resulting ppt was collected by filtration and washed with water. After drying in vacuo, the title compound was obtained as a pale yellow solid (41 mg).

後処理

  1. filtrationThe resulting ppt was collected by filtration
  2. washwashed with water
  3. customAfter drying in vacuo

出典と根拠

ORDレコード
ord-bdd54befa5c6498b8ef0af1f15061c0f
出典データセット
uspto-grants-2005_03
特許番号
US06861438B2

反応ノート

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