1-Methylpiperazine → 6-(4-biphenylyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

反応式

[C:1]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH2:18]OS(C)(=O)=O)[C:10](=[O:17])[N:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:12]=2)=[CH:3][CH:2]=1.[CH3:30][N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[C:1]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH2:18][N:34]3[CH2:35][CH2:36][N:31]([CH3:30])[CH2:32][CH2:33]3)[C:10](=[O:17])[N:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:12]=2)=[CH:3][CH:2]=1

参加物

反応物 2

HCID 531671-Methylpiperazine

HCID 219915756-(4-biphenylyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one

生成物 1

HCID 219916926-(4-biphenylyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one収率 68.2%

実験手順

Following the procedure of Example 1(10), 6-(4-biphenylyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 68.2%).

後処理

customwere reacted

出典と根拠

ORDレコード: ord-4d9331765c144088b656cf08c8d4eb63
出典データセット: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06861428B2

反応ノート

読み込み中…