3,4-Difluorobenzyl Chloride → 4-carboxy-2-(3,4-difluorobenzyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 982830

反応式

HRID 982830 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:15]([O:17]C)=[O:16])[C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[CH3:19].[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[F:29])[CH2:24]Cl>>[C:15]([C:10]1[C:11](=[O:14])[N:12]([CH2:24][C:23]2[CH:26]=[CH:27][C:28]([F:29])=[C:21]([F:20])[CH:22]=2)[N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:19])[CH:4]=2)[CH:9]=1)([OH:17])=[O:16]

参加物

3

反応物 2

HCID 27369543,4-Difluorobenzyl ChlorideHCID 219914596-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

生成物 1

HCID 225623084-carboxy-2-(3,4-difluorobenzyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one収率 66.7%

実験手順

Following the procedure of Example 1(6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3,4-difluorobenzyl chloride were reacted. Without purification, the reaction product was reacted further following the procedure of Example 1(7) to yield the title compound as a pale yellow solid (yield: 66.7%).

後処理

  1. customwere reacted
  2. customWithout purification
  3. customthe reaction product was reacted further

出典と根拠

ORDレコード
ord-6e924e461c0c4b41ac1a9932e726075d
出典データセット
uspto-grants-2005_03
特許番号
US06861428B2

関連ノート

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