Water → HCID 22561880、化合物
反応式
[CH3:1][C:2]1[NH:6][CH:5]=[C:4]([CH2:7][C:8]([OH:10])=[O:9])[CH:3]=1.[CH:11](OCC)(OCC)[O:12]CC.O>C(O)(C(F)(F)F)=O>[CH:11]([C:5]1[NH:6][C:2]([CH3:1])=[CH:3][C:4]=1[CH2:7][C:8]([OH:10])=[O:9])=[O:12]参加物
5
実験手順
To a solution of (5-methyl-1H-pyrrol-3-yl)-acetic acid (8.2 mmol) in TFA (6 mL) at 0° C. was added triethyl orthoformate (6 mL), it was then at 0° C. for 10 mins and at rt for 0.5 hours. The reaction was poured into water, extracted with ethyl acetate, dried and concentrated. The residue was purified on a silica gel column to give 1.15 g (84%) of (2-formyl-5-methyl-1H-pyrrol-3-yl) acetic acid.
後処理
- waitat rt for 0.5 hours
- extractionextracted with ethyl acetate
- customdried
- concentrationconcentrated
- customThe residue was purified on a silica gel column
出典と根拠
- ORDレコード
- ord-29b9a51f38b94d8abc187be66ef61641
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06861418B2
反応ノート
読み込み中…