Cyclamate → Cyclohexylsulfamyl chloride

HRID 983386

反応式

HRID 983386 の反応式
[CH:1]1([NH:7][S:8](=[O:11])(=O)[OH:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)(Cl)[Cl:13]>C1C=CC=CC=1>[CH:1]1([NH:7][S:8]([Cl:13])(=[O:11])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 7533CyclamateHCID 24819Phosphorus pentachloride

生成物 1

HCID 12914615Cyclohexylsulfamyl chloride収率 91%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a solution of cyclohexylsulfamic acid (5 g, 27.9 mmol) in benzene (30 mL) was added dropwise phosphorus pentachloride (6.4 g, 30.7 mmol), and the mixture heated at reflux for 4 h. After the solvent was removed, the residue was distilled under reduced pressure to give the title compound (5 g, 91%).

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for 4 h
  3. customAfter the solvent was removed
  4. distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-a76075b7f38b47758adefd0f59f0adb2
出典データセット
uspto-grants-2005_03
特許番号
US06864249B2

関連ノート

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