1-(1-Benzylpyrrolidin-3-yl)ethan-1-one → HCID 22560190、化合物

HRID 983396ノート

反応式

HRID 983396 の反応式
[C:1]([CH:4]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:5]1)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[CH2:9]([N:6]1[CH2:7][CH2:8][CH:4]([CH:1]([OH:3])[CH3:2])[CH2:5]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 3579521-(1-Benzylpyrrolidin-3-yl)ethan-1-oneHCID 4311764Sodium borohydride

生成物 1

HCID 22560190HCID 22560190、化合物収率 74.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 5° C. solution of 3-acetyl-1-benzylpyrrolidine (1 g, 4.9 mmol [L. E. Overman, J. Am. Chem. Soc. 1983, 105, 6622]) in methanol (10 mL) was added portionwise sodium borohydride (0.37 g, 9.8 mmol). After stirring at room temperature for 17 hours, the mixture was concentrated, diluted with ethyl acetate, washed with water, brine, dried with sodium sulfate and concentrated to afford the title compound (0.75 g). MSCI: m/z=206 (MH+).

後処理

  1. concentrationthe mixture was concentrated
  2. additiondiluted with ethyl acetate
  3. washwashed with water, brine
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-8484d10411fa4e2f8592a0971fe058fc
出典データセット
uspto-grants-2005_03
特許番号
US06864259B2

反応ノート

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