Lithium iodide → 4-(6-Cyano-5-hydroxy-pyridin-2-yl)-benzoic acid ethyl ester

HRID 983415ノート

反応式

HRID 983415 の反応式
[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17]C)=[C:13]([C:19]#[N:20])[N:12]=2)=[CH:7][CH:6]=1)[CH3:2].[Li+].[I-]>N1C(C)=CC(C)=CC=1C>[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([C:19]#[N:20])[N:12]=2)=[CH:9][CH:10]=1)[CH3:2]

参加物

4

反応物 2

HCID 66321Lithium iodideHCID 693568724-(6-Cyano-5-methoxy-pyridin-2-yl)-benzoic acid ethyl ester

生成物 1

HCID 693595274-(6-Cyano-5-hydroxy-pyridin-2-yl)-benzoic acid ethyl ester

試薬・触媒・溶媒 1

HCID 79532,4,6-Trimethylpyridine溶媒

反応条件

温度
120 °C

実験手順

A solution of 4-(6-cyano-5-methoxy-pyridin-2-yl)-benzoic acid ethyl ester from Example 13d in collidine is treated with LiI and heated at 120° C. for 24 h. The reaction mixture is evaporated, the residue is taken into water and neutralized with 1 N HCl. The resulting precipitate is collected and dried to give 4-(6-cyano-5-hydroxy-pyridin-2-yl)-benzoic acid ethyl ester.

後処理

  1. customThe reaction mixture is evaporated
  2. customThe resulting precipitate is collected
  3. customdried

出典と根拠

ORDレコード
ord-da5589dd4c5e468882903486c4d0c31f
出典データセット
uspto-grants-2005_03
特許番号
US06864267B2

反応ノート

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