Diethyl Sulfate → 2-Bromophenetole

HRID 983517

反応式

HRID 983517 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].S(OCC)(O[CH2:13][CH3:14])(=O)=O>[OH-].[Na+]>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 6163Diethyl SulfateHCID 72442-Bromophenol

生成物 1

HCID 685002-Bromophenetole

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of 17.5 g of 2-bromophenol, 66 ml of diethyl sulphate and 170 ml of 10% NaOH solution is refluxed for 2 hours. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is washed with 2N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 19.6 g of the expected product are obtained.

後処理

  1. temperatureis refluxed for 2 hours
  2. extractionit is extracted with EtOAc
  3. washthe organic phase is washed with 2N NaOH solution
  4. dry with materialdried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-0712c5114dfc483784435abdf4cff346
出典データセット
uspto-grants-2005_03
特許番号
US06864277B2

関連ノート

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