Diethyl Sulfate → 2-Bromophenetole
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].S(OCC)(O[CH2:13][CH3:14])(=O)=O>[OH-].[Na+]>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:13][CH3:14]参加物
4
実験手順
A mixture of 17.5 g of 2-bromophenol, 66 ml of diethyl sulphate and 170 ml of 10% NaOH solution is refluxed for 2 hours. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is washed with 2N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 19.6 g of the expected product are obtained.
後処理
- temperatureis refluxed for 2 hours
- extractionit is extracted with EtOAc
- washthe organic phase is washed with 2N NaOH solution
- dry with materialdried over Na2SO4
- customthe solvent is evaporated off under vacuum
出典と根拠
- ORDレコード
- ord-0712c5114dfc483784435abdf4cff346
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06864277B2
反応ノート
読み込み中…