Hydroquinone → 1,4-dihexyloxybenzene
反応式
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].[CH2:9](Br)[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[Na+].[I-]>C(O)C>[CH2:9]([O:2][C:1]1[CH:8]=[CH:7][C:5]([O:6][CH2:7][CH2:8][CH2:1][CH2:3][CH2:4][CH3:5])=[CH:4][CH:3]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]参加物
5
実験手順
Under argon atmosphere, 6.90 g (300 mmol) of Na is reacted with 200 ml of absolute ethanol. Then, 16.5 g (150 mmol) of hydroquinone 5 is added, followed by 42.2 ml (300 mmol) of hexylbromide and 200 mg of anhydrous NaI. The mixture is refluxed overnight. Ethanol is evaporated under reduced pressure and water (150 ml) is added. The product is extracted with dichloromethane and dried over MgSO4. After filtration, the solvents are removed and the crude compound is recrystallized from ethanol.
後処理
- temperatureThe mixture is refluxed overnight
- customEthanol is evaporated under reduced pressure and water (150 ml)
- additionis added
- extractionThe product is extracted with dichloromethane
- dry with materialdried over MgSO4
- filtrationAfter filtration
- customthe solvents are removed
- customthe crude compound is recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-b267670f34114592ad36800ae4fd32a8
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06864347B2
反応ノート
読み込み中…