Diethyl (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonate → HCID 9813750、化合物
反応式
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([CH2:11][CH:12]([C:18]([O:20]CC)=[O:19])[C:13]([O:15]CC)=[O:14])=[CH:4][N:3]=1>[OH-].[Na+].C(O)C>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([CH2:11][CH:12]([C:18]([OH:20])=[O:19])[C:13]([OH:15])=[O:14])=[CH:4][N:3]=1参加物
4
実験手順
The product of Example 25, of structure XXIX (620 mg, 2.0 mmol) was dissolved in aqueous NaOH (2 M, 4 mL) and stirred at room temperature for 1 hour. The reaction was quenched by adding 6 N HCl to give pH 4 to 5. The solution was diluted with 95% ethanol, separated from the precipitated salts and evaporated to give 540 mg.
後処理
- customThe reaction was quenched
- additionby adding 6 N HCl
- customto give pH 4 to 5
- customseparated from the precipitated salts
- customevaporated
- customto give 540 mg
出典と根拠
- ORDレコード
- ord-2bedc89470b54416884d1fe396eea9e3
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06867215B2
反応ノート
読み込み中…