Tetrahydrofuran → 2-[4-(4-Fluorophenoxy)phenyl]pyrimidine-4-carboxamide

HRID 984058ノート

反応式

HRID 984058 の反応式
FC1C=CC(OC2C=C[C:10]([C:13]3[N:18]=C(C)C=CN=3)=[CH:9][CH:8]=2)=CC=1.CC(C)([O-:25])C.[K+].C1COCC1.C(O)(=O)C.[F:37][C:38]1[CH:53]=[CH:52][C:41]([O:42][C:43]2[CH:51]=[CH:50][C:46]([C:47]([NH2:49])=[NH:48])=[CH:45][CH:44]=2)=[CH:40][CH:39]=1.COC(OC)CC(=O)C>CN(C=O)C>[F:37][C:38]1[CH:39]=[CH:40][C:41]([O:42][C:43]2[CH:51]=[CH:50][C:46]([C:47]3[N:49]=[C:10]([C:13]([NH2:18])=[O:25])[CH:9]=[CH:8][N:48]=3)=[CH:45][CH:44]=2)=[CH:52][CH:53]=1

参加物

7

反応物 5

HCID 8028TetrahydrofuranHCID 2285484,4-Dimethoxy-2-butanoneHCID 99655052-[4-(4-Fluorophenoxy)phenyl]-4-methylpyrimidineHCID 23665647Potassium tert-butoxideHCID 685220074-(4-Fluorophenoxy)benzamidine acetate

生成物 1

HCID 98362702-[4-(4-Fluorophenoxy)phenyl]pyrimidine-4-carboxamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

2-[4-(4-Fluorophenoxy)phenyl]-4-methylpyrimidine: A 1M solution of potassium tert-butoxide in THF (11 mL, 11 mmol) was added via syringe to a solution of 4-(4-fluorophenoxy)benzamidine acetate (2.92 g, 10.2 mmol) in DMF. The resulting mixture was heated at 100° C. for 2 hours. Acetylacetaldehyde dimethyl acetal (2 mL, 13.6 mmol) was added via syringe. The reaction was maintained between 100°-110° C. overnight when TLC indicated complete reaction. The reaction was allowed to cool to room temperature and partitioned between water and EtOAc. The aqueous layer was extracted with EtOAc and the combined organic layers were washed with water (3 times), dried over MgSO4, filtered, and evaporated under reduced pressure to give the desired product as a yellow oil. 1H NMR (CDCl3): δ8.60 (d, J=5.1, 1H), 8.40 (d, J=9.0, 2H), 7.05-7.00 (m, 7H), 2.57 (s, 3H). This material was carried on without further purification.

後処理

  1. temperatureThe reaction was maintained between 100°-110° C. overnight when TLC
  2. customreaction
  3. temperatureto cool to room temperature
  4. custompartitioned between water and EtOAc
  5. extractionThe aqueous layer was extracted with EtOAc
  6. washthe combined organic layers were washed with water (3 times)
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-8d720f4f29784f4684d127496d26e028
出典データセット
uspto-grants-2005_03
特許番号
US06867210B2

反応ノート

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