4-Acetylphenylboronic acid → (E)-1-[4'-(3-hydroxy-1-methyl-propenyl)-biphenyl-4-yl]-ethanone

反応式

[C:1]([C:4]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].I[C:14]1[CH:19]=[CH:18][C:17](/[C:20](/[CH3:24])=[CH:21]/[CH2:22][OH:23])=[CH:16][CH:15]=1>>[OH:23][CH2:22]/[CH:21]=[C:20](/[C:17]1[CH:18]=[CH:19][C:14]([C:7]2[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH3:2])=[CH:5][CH:6]=2)=[CH:15][CH:16]=1)\[CH3:24]

参加物

反応物 2

HCID 37021224-Acetylphenylboronic acid

HCID 11437263(E)-3-(4-iodophenyl)-but-2-en-1-ol

生成物 1

HCID 11425603(E)-1-[4'-(3-hydroxy-1-methyl-propenyl)-biphenyl-4-yl]-ethanone

実験手順

The pale yellow solid, (E)-1-[4′-(3-hydroxy-1-methyl-propenyl)-biphenyl-4-yl]-ethanone was prepared from 4-acetylphenyl boronic acid and (E)-3-(4-iodophenyl)-but-2-en-1-ol by a procedure analogous to that described in example 54a.

出典と根拠

ORDレコード: ord-a5ace52d76e54c078b3bc0b3d832f7e3
出典データセット: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06867218B2

反応ノート

読み込み中…