Ethyl Acetate → HCID 178459251、化合物

HRID 984809ノート

反応式

HRID 984809 の反応式
C(OC(=O)[NH:10][CH2:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]([OH:21])([CH3:20])[CH3:19])[CH2:14][CH2:13]1)C1C=CC=CC=1.C(OCC)(=O)C>[OH-].[OH-].[Pd+2].CO>[NH2:10][CH2:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]([OH:21])([CH3:19])[CH3:20])[CH2:14][CH2:13]1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 178459252HCID 178459252、化合物

生成物 1

HCID 178459251HCID 178459251、化合物収率 85.7%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A 500 mL Parr bottle was charged with 150 mg Pd(OH)2, 3.3 g (10.7 mmol) trans-[4-(1-hydroxy-1-methyl-ethyl)-cyclohexylmethyl]-carbamic acid benzyl ester, 100 mL ethyl acetate and 100 mL MeOH. The bottle was placed under 50 psi H2 and shaken for 1 hour. The material was filtered through Celite and concentrated to give 1.57 g of a white solid.

後処理

  1. filtrationThe material was filtered through Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-68ec16604d524769bc0b383fd1cd0322
出典データセット
uspto-grants-2005_03
特許番号
US06869945B2

反応ノート

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