8-Benzyloxy-6-methoxymethyl-2,3-dimethylimidazo[1,2-a]pyridine → 6-Methoxymethyl-2,3-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-one

HRID 985107ノート

反応式

HRID 985107 の反応式
C([O:8][C:9]1[C:10]2[N:11]([C:18]([CH3:22])=[C:19]([CH3:21])[N:20]=2)[CH:12]=[C:13]([CH2:15][O:16][CH3:17])[CH:14]=1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:17][O:16][CH2:15][CH:13]1[CH2:12][N:11]2[C:18]([CH3:22])=[C:19]([CH3:21])[N:20]=[C:10]2[C:9](=[O:8])[CH2:14]1

参加物

5

反応物 2

HCID 218739748-Benzyloxy-6-methoxymethyl-2,3-dimethylimidazo[1,2-a]pyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 218739786-Methoxymethyl-2,3-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

19.2 g of 8-benzyloxy-6-methoxymethyl-2,3-dimethylimidazo[1,2-a]pyridine, dissolved in 100 ml of methanol, are treated with 1.9 g of palladium (10% strength on activated carbon, Merck) and hydrogenated with hydrogen at 80° C. using a pressure of 50 bar. After absorption of hydrogen is complete, the catalyst is filtered off, washed with methanol and methylene chloride and the combined filtrate is concentrated to dryness in vacuo. After purification on silica gel (eluent: methylene chloride/methanol=13/1), 7.6 g of the title compound of melting point 103-104° C. are obtained.

後処理

  1. customAfter absorption of hydrogen
  2. filtrationthe catalyst is filtered off
  3. washwashed with methanol and methylene chloride
  4. concentrationthe combined filtrate is concentrated to dryness in vacuo
  5. customAfter purification on silica gel (eluent: methylene chloride/methanol=13/1), 7.6 g of the title compound of melting point 103-104° C.
  6. customare obtained

出典と根拠

ORDレコード
ord-872f340cf1af4aca9370b7461bc970d1
出典データセット
uspto-grants-2005_03
特許番号
US06869949B2

反応ノート

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