Hydrochloric Acid → Biphenyl phenyl-carbinol

HRID 985131

反応式

HRID 985131 の反応式
[C:1]1([C:7]2[CH:20]=[CH:19][C:10]([C:11](C3C=CC=CC=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].O.Cl>C(O)C>[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[CH:19][CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]1([CH2:11][OH:12])[CH:19]=[CH:20][CH:7]=[CH:8][CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 750404-Benzoylbiphenyl3 回HCID 4311764Sodium borohydride

生成物 1

HCID 21946058Biphenyl phenyl-carbinol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The method of synthesis presented in Ger.Pat. 2,461,406 uses 4-phenylbenzophenone as partition reactant, and has 2 or three steps, depending on the variation of synthesis to use. One of the variations comprises the dissolution of 4-phenylbenzophenone in ethanol, then adding sodium borohydride in a 1:2 molar relation to 4-phenyl benzophenone, for the reduction of ketone to alcohol. The system is heated to reflux during fifteen hours, it is let to cool down and the reaction mixture is hydrolyzed with water acidulated with HCl, the solid obtained is purified by recrystallization in ethanol. 89% of the theoretical yield of biphenyl-phenyl-carbinol is obtained.

後処理

  1. customThe method of synthesis
  2. customas partition reactant
  3. customdepending on the variation of synthesis
  4. temperatureThe system is heated
  5. temperatureto reflux during fifteen hours
  6. temperatureto cool down
  7. customthe solid obtained
  8. customis purified by recrystallization in ethanol

出典と根拠

ORDレコード
ord-3ada3ac8b0e14d989db98a999ea5f2bc
出典データセット
uspto-grants-2005_03
特許番号
US06870057B1

関連ノート

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