Benzene, 1-iodo-2-(trifluoromethyl)- → 1,1'-Biphenyl, 2,2'-bis(trifluoromethyl)-
反応式
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9]>[Cu].CN(C=O)C>[F:9][C:8]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9]参加物
4
実験手順
To a 2-L three-necked, round-bottom flask fitted with a mechanical stirrer and a condenser was added 507.5 g of 2-iodotrifluoromethylbenzene (1.86 mol), 282.0 g of copper powder and 400 ml of DMF. The reaction mixture was stirred and heated at reflux for 24 hours and filtered. The filtrate was distilled under reduced pressure to yield 211.8 g (78%) of a light yellow oil.
後処理
- customTo a 2-L three-necked, round-bottom flask fitted with a mechanical stirrer and a condenser
- temperatureheated
- temperatureat reflux for 24 hours
- filtrationfiltered
- distillationThe filtrate was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-1da025868e374fa18e9c40a21616e6b3
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06870978B2
反応ノート
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