Trifluoroacetic acid → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate
反応式
C(O[N:6]([C:10]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]=[CH:12][CH:11]=1)[C:7](C)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:7][NH:6][C:10]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]=[CH:12][CH:11]=1参加物
4
実験手順
To a solution of ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate (3.56 g, 12.1 mmol) in dichloromethane (15 ml) was added trifluoroacetic acid (8 ml). The reaction was stirred for 16 h. The solvent was removed under vacuum and the crude product was chromatographed over silica gel to yield 2.2 g (100%) of Ethyl 2-[6-(methylamino)-2-pyridyl]acetate.
後処理
- customThe solvent was removed under vacuum
- customthe crude product was chromatographed over silica gel
出典と根拠
- ORDレコード
- ord-fe756ca3d2c144cfbc76617fb511544d
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06872730B2
反応ノート
読み込み中…