Trifluoroacetic acid → (2R)-2-Amino-3-phenylpropyl 2,2-dimethylpropanoate
反応式
[C:1]([O:7][CH2:8][C@H:9]([NH:17]C(OC(C)(C)C)=O)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].FC(F)(F)C(O)=O>C(Cl)Cl>[C:1]([O:7][CH2:8][C@H:9]([NH2:17])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]参加物
4
実験手順
A cooled solution of compound 94 (1.006 g, 3 mmol) in CH2Cl2 (10 ml) at 0° C. was treated with trifluoroacetic acid (2.5 ml) and stirred for 1 hr at room temperature. The mixture was concentrated in vacuo to give compound 96 as a yellow oil which was used for the next step without further purification.
後処理
- concentrationThe mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-3f18fdce92c64c9a8e2c28d655cdfefb
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06872748B2
反応ノート
読み込み中…