Pyridine → 3-Hydroxypropylpyridinium tosylate

反応式

[S:1]([O:11][CH2:12][CH2:13][CH2:14]O)([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2].[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[S:1]([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)([O-:11])(=[O:3])=[O:2].[OH:11][CH2:12][CH2:13][CH2:14][N+:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

反応物 2

HCID 1049Pyridine

HCID 119613563-Hydroxypropyl 4-methylbenzenesulfonate

生成物 1

HCID 201593883-Hydroxypropylpyridinium tosylate

反応条件

温度: 60 °C

実験手順

In 10 ml of pyridine was dissolved 4.0 g of 1,3-propanediol monotosylate and the mixture was stirred at 60° C. overnight. The mixture was concentrated under reduced pressure to give the desired compound as a colorless oily material. Yield: 5.6 g (quantitative).

後処理

concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-41114b503927417cbcff94c88596e1fa
出典データセット: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04710579

反応ノート

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