3-Methylpiperidine → HCID 13336377、化合物

HRID 986277ノート

反応式

HRID 986277 の反応式
[C:1]1([C:7]2[N:16]=[C:15]([C:17]([O:19]CC)=O)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][CH:23]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]1.C([Li])CCC>CCCCCC.O1CCCC1>[CH3:22][CH:23]1[CH2:28][CH2:27][CH2:26][N:25]([C:17]([C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:16]=2)=[O:19])[CH2:24]1

参加物

6

反応物 3

HCID 790813-MethylpiperidineHCID 20158356HCID 20158356、化合物HCID 178418339Butyllithium

生成物 1

HCID 13336377HCID 13336377、化合物

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8058Hexane溶媒

実験手順

The procedure of Example 24 is followed using ethyl 2-phenylquinazoline-4-carboxylate (3 g), 3-methylpiperidine (3 ml), a 1.6M solution of butyllithium in hexane (15 ml) and tetrahydrofuran (20 ml) as the starting materials. After recrystallisation from isopropyl ether, 3-methyl-1-[(2-phenylquinazolin-4-yl)-carbonyl]piperidine (1 g), melting at 116° C., is obtained.

後処理

  1. customAfter recrystallisation from isopropyl ether, 3-methyl-1-[(2-phenylquinazolin-4-yl)-carbonyl]piperidine (1 g), melting at 116° C.
  2. customis obtained

出典と根拠

ORDレコード
ord-9f82affbac3a49ba8b21df9d3d50c4f4
出典データセット
uspto-grants-1987_12
特許番号
US04711890

反応ノート

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