Hydrazine hydrate (1:1) → HCID 14032921、化合物
反応式
C(O[C:4]([NH:6][CH2:7][C:8]([C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[N:12][C:11]=1[CH3:18])=O)=[O:5])C.O.[NH2:20][NH2:21]>C(O)C>[CH3:18][C:11]1[N:12]=[C:13]2[N:17]([C:10]=1[C:8]1[CH2:7][NH:6][C:4](=[O:5])[NH:20][N:21]=1)[CH:16]=[CH:15][S:14]2参加物
4
実験手順
A mixture of 7 g of 5-ethoxycarbonylaminoacetyl-6-methylimidazo[2,1-b]thiazole, 100 ml of ethanol and 8 ml of 100% hydrazine hydrate is refluxed under heating for 2 days. After cooling, crystals are collected by filtration and recrystallized from a mixed solvent of chloroform and methanol to give 3.4 g of 6-(6-methylimidazo[2,1-b]thiazol-5-yl)-4,5-dihydro-2H-1,2,4 triazin-3-one as white crystals, melting at 293°-295° C. with decomposition.
後処理
- temperatureis refluxed
- temperatureunder heating for 2 days
- temperatureAfter cooling
- filtrationcrystals are collected by filtration
- customrecrystallized from a mixed solvent of chloroform and methanol
出典と根拠
- ORDレコード
- ord-a1f0c89577d348978c9f069fd2b5e834
- 出典データセット
- uspto-grants-1987_12
- 特許番号
- US04713381
反応ノート
読み込み中…