Thionyl Chloride → 3-[4-(Pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride

HRID 986429ノート

反応式

HRID 986429 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16]O)=[CH:10][CH:9]=2)[CH:2]=1.S(Cl)([Cl:20])=O>C(Cl)Cl>[ClH:20].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][Cl:20])=[CH:10][CH:9]=2)[CH:2]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 138227803-[4-(Pyridin-3-ylmethyl)phenyl]propanol

生成物 1

HCID 201486293-[4-(Pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 10 ml of methylene chloride was dissolved 500 mg of 3-[4-(pyridin-3-ylmethyl)phenyl]propanol, and 0.80 ml of thionyl chloride was added to the resulting solution with ice-cooling, after which the resulting mixture was subjected to reaction under reflux for one hour. The solvent and the excessive thionyl chloride were removed by distillation under reduced pressure, to obtain 3-[4-(pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride as the residue. This residue was dissolved in 4 ml of dimethyl sulfoxide.

後処理

  1. additionwas added to the resulting solution with ice-
  2. temperaturecooling
  3. customafter which the resulting mixture was subjected to reaction
  4. temperatureunder reflux for one hour
  5. customThe solvent and the excessive thionyl chloride were removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-b4e700d2813443a7ac9f8b27169f01d1
出典データセット
uspto-grants-1987_12
特許番号
US04713387

反応ノート

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