Thiophenol → Ethyl Fluoro(phenylthio)acetate
反応式
CC[O-].[Na+].[C:5]1([SH:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[F:12][CH:13](Br)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>O1CCCC1>[F:12][CH:13]([S:11][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:14]([O:16][CH2:17][CH3:18])=[O:15]参加物
5
実験手順
To 150 ml of tetrahydrofuran (THF) were added 6.5 g (0.1 mole) of pulverized EtONa and 11.1 g (0.1 mole) of thiophenol and the mixture was refluxed for 10 minutes. Thereto was added 18.5 g (0.1 mole) of ethyl fluorobromoacetate and the mixture was refluxed for one hour with stirring. THF was removed by an evaporator and the precipitated NaBr was filtered. The organic layer was washed with water, dried and distilled to obtain 19.2 g (90%) of ethyl fluoro(phenylthio)acetate.
後処理
- temperaturethe mixture was refluxed for 10 minutes
- temperaturethe mixture was refluxed for one hour
- customTHF was removed by an evaporator
- filtrationthe precipitated NaBr was filtered
- washThe organic layer was washed with water
- customdried
- distillationdistilled
出典と根拠
- ORDレコード
- ord-034b39cd848445a797046d51f9e66e48
- 出典データセット
- uspto-grants-1987_12
- 特許番号
- US04713469
反応ノート
読み込み中…