Hydrochloric Acid → HCID 13628314、化合物

HRID 986873ノート

反応式

HRID 986873 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)([O-])=O.O.Cl>C(O)C.CC(C)=O.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 12095Glycine, N-(4-nitrophenyl)-

生成物 1

HCID 13628314HCID 13628314、化合物収率 114.3%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 180Acetone溶媒HCID 702Ethanol溶媒

実験手順

1 g (5 mmol) of (4-nitrophenyl)glycine is dissolved in 20 ml of ethanol, 5 ml of water and 2.5 ml (2.5 eq) of 5N hydrochloric acid in a 250 ml glass reactor (Paar apparatus). 1 g of palladium-on-charcoal (50% moisture and 10% active) is then introduced. The mixture is hydrogenated under a pressure of approximately 2.76×105 Pa for 1 hour 30 minutes at a temperature of 20° C. After filtering through celite, the filtrate is evaporated to dryness. A white solid is obtained which is taken up in 50 ml of acetone, filtered and dried under vacuum at 40° C. 0.95 g of a white powder is obtained.

後処理

  1. filtrationAfter filtering through celite
  2. customthe filtrate is evaporated to dryness
  3. customA white solid is obtained which
  4. filtrationfiltered
  5. customdried under vacuum at 40° C

出典と根拠

ORDレコード
ord-1ad1bbc28b9c497484ac875239a4cd45
出典データセット
uspto-grants-2003_10
特許番号
US06630004B1

反応ノート

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