Perfluoro-2-butanone → HCID 131723633、化合物

HRID 986885ノート

反応式

HRID 986885 の反応式
[F:1][C:2]([F:13])([F:12])[C:3](=[O:11])[C:4]([F:10])([F:9])[C:5]([F:8])([F:7])[F:6]>N1C=CC=CC=1>[C:2]([C:3]([C:4]([C:5]([F:6])([F:7])[F:8])([F:9])[F:10])=[O:11])([F:13])([F:12])[F:1].[F:1][C:2]([F:12])([F:13])[C:3](=[O:11])[C:4]([F:10])([F:9])[C:5]([F:8])([F:7])[F:6]

参加物

3

反応物 1

HCID 3429852Perfluoro-2-butanone

生成物 1

HCID 131723633HCID 131723633、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

1341 g of sec-butyl acetate was fluorinated using essentially the same procedure as described in U.S. Pat. No. 5,488,142 (Fall et al.). The resulting perfluorinated ester (688 g) was isolated from the reaction mixture by fractionation. The ester was then decomposed according to the method described by Moore in U.S. Pat. No. 5,466,877 wherein the ester was added dropwise to a 1-liter, 3-neck flask equipped with a magnetic stirrer, dry ice condenser and temperature probe containing 0.5 mL of pyridine. The pot temperature was maintained at about −10° C., during which time the conversion to the ketone occurred. The gaseous ketone product was fractionated to give 435 g. of 1,1,1,3,3,4,4,4-octafluoro-butan-2-one, having a boiling point of 0° C., with purity of 99.7% as determined by gas chromatography and mass spectroscopy.

後処理

  1. customequipped with a magnetic stirrer, dry ice condenser
  2. customto give 435 g

出典と根拠

ORDレコード
ord-7f7615717e9244ef916e285590d6f7f7
出典データセット
uspto-grants-2003_10
特許番号
US06630075B2

反応ノート

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