Sodium borohydride → 2-Ethoxy-3-{3-[3-(4-methylsulfonyloxyphenyl)propoxy]phenyl}propanol
反応式
[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][S:28]([CH3:31])(=[O:30])=[O:29])=[CH:23][CH:22]=2)[CH:12]=1)[C:5](OCC)=[O:6])[CH3:2].[BH4-].[Na+]>>[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][S:28]([CH3:31])(=[O:29])=[O:30])=[CH:23][CH:22]=2)[CH:12]=1)[CH2:5][OH:6])[CH3:2]参加物
3
実験手順
The compound was synthesised in an analogous method to Example 1 using ethyl 2-ethoxy-3-{3-[3-(4-methylsulfonyloxyphenyl)propoxy]phenyl}propanoate (0.642 g, 1.42 mmol) and sodium borohydride (93.26 mg, 2.47 mmol). The reaction was quenched after 28 hours to give 0.574 g (yield 99%) of the desired product.
後処理
- customThe reaction was quenched after 28 hours
出典と根拠
- ORDレコード
- ord-85ddad4f97e44a0a95735f7385907e8f
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06630509B2
反応ノート
読み込み中…