2-[(3-Nitro-4-quinolinyl)amino]ethanol → 2-[(3-Amino-4-quinolinyl)amino]ethanol
反応式
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][OH:17])=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>[Pt].C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][OH:17])=[CH:11][CH:10]=[CH:9][CH:8]=2参加物
4
実験手順
2-[(3-Nitro4-quinolinyl)amino]ethanol (6 g) was combined with ethanol (200 mL) and platinum on carbon catalyst. The mixture was hydrogenated on a Parr apparatus. This procedure was repeated four additional times using a total of 30 g of starting material. The mixtures from all five hydrogenations were combined and then filtered through a layer of Celite® filter aid to remove the catalyst. The filtrate was concentrated under vacuum to provide crude 2-[(3-amino-4-quinolinyl)amino]ethanol.
後処理
- filtrationfiltered through a layer of Celite®
- filtrationfilter aid
- customto remove the catalyst
- concentrationThe filtrate was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-e4c6a991ae1f4abaaed806ad63c80912
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06630588B2
反応ノート
読み込み中…