Hydrogen Peroxide → [3-(4-Bromo-benzyl)-3H-imidazol-4-YL]-methanol

HRID 987198

反応式

HRID 987198 の反応式
[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[C:8]2S)=[CH:4][CH:3]=1.OO.[OH-].[Na+]>CO.O[W](O)(=O)=O>[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[CH:8]2)=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 178519844HCID 178519844、化合物

生成物 1

HCID 10199227[3-(4-Bromo-benzyl)-3H-imidazol-4-YL]-methanol収率 82.4%

試薬・触媒・溶媒 2

HCID 1152Tungstic acid触媒HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

1-(4-Bromobenzyl)-2-mercapto-5-hydroxymethylimidazole(1.5 g, 5 mmol) and tungstic acid(12.5 mg, 1 mol %) were suspended in 7 ml of methanol. The suspension was warmed to 40° C. and then, 30% hydrogen peroxide was slowly added dropwise. After about 2 hours, the mixture was cooled and neutralized with 1 N sodium hydroxide solution, and the precipitate was filtered. The obtained solid was washed twice with 5 ml of distilled water and 5 ml of isopropyl ether, respectively, to give 1.1 g(Yield 82%) of the title compound as a white powder.

後処理

  1. temperaturethe mixture was cooled
  2. filtrationthe precipitate was filtered
  3. washThe obtained solid was washed twice with 5 ml of distilled water and 5 ml of isopropyl ether

出典と根拠

ORDレコード
ord-0cd13cdc1482418189e4b7faf9558634
出典データセット
uspto-grants-2003_10
特許番号
US06630593B1

関連ノート

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