Octahydroindolizin-7-one → Octahydroindolizin-7-amine

(±)-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one (5.0 g, 35.9 mmol) was dissolved in a solution of 2M ammonia/ethanol (54 ml, 108 mmol calculated in terms of ammonia). The resulting solution was stirred at room temperature in an atmosphere of hydrogen in the presence of 10% palladium on charcoal (500 mg) for 4 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (4.91 g) as a colorless oil (yield 98%).

1. filtrationAt the end of this time, the reaction mixture was filtered
2. customto remove the catalyst
3. concentrationthe filtrate was concentrated by evaporation under reduced pressure

ORDレコード

ord-d4445a4fa7c3408b8f17654f35a6a381

出典データセット

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07091352B2