2-Naphthylamine → 2-[N-(naphth-2-yl)amino]butanoic Acid Ethyl Ester

HRID 987764

反応式

HRID 987764 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.Br[CH:13]([CH2:19][CH3:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(Cl)(Cl)Cl>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1)[CH2:19][CH3:20])[CH3:18]

参加物

4

反応物 2

HCID 70572-NaphthylamineHCID 79039Butanoic acid, 2-bromo-, ethyl ester

生成物 1

HCID 101313222-[N-(naphth-2-yl)amino]butanoic Acid Ethyl Ester

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Following General Procedure AJ above and using 2-aminonaphthalene (Aldrich) and ethyl 2-bromobutyrate (Aldrich), the title compound was prepared as a solid, m.p. 81-83° C. The reaction was monitored by silica gel tlc (Rf=0.5 in CHCl3). Purification was by chromatography (silica gel using chloroform as the eluant).

後処理

  1. customPurification

出典と根拠

ORDレコード
ord-6d8e30146e394ad78b87b0ef3caced29
出典データセット
uspto-grants-2003_10
特許番号
US06632811B2

関連ノート

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