反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[H-].[Na+].[CH3:11][O:12][C:13](=[O:35])[CH:14]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:15]OS(C1C=CC(C)=CC=1)(=O)=O>CN(C)C=O>[CH3:11][O:12][C:13](=[O:35])[CH:14]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:15][S:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1参加物
実験手順
A stirred solution of 4-fluorothiophenol (1.24 g, 9.65 mmol) in N,N-dimethyl formamide (10 ml) was treated with sodium hydride (240 mg, 9.37 mmol) and the reaction mixture was stirred at room temperature for 30 minutes. 2-tert-Butoxycarbonylamino-3-(toluene-4-sulfonyloxy)-propionic acid methyl ester (3 g, 8.04 mmol) in N,N dimethyl formamide (ml) was added, the resulting mixture was stirred for two hours and then concentrated in vacuo. The residue was dissolved in ethyl acetate (100 ml) and washed with water (2*80 ml) and brine. The organic layer was dried (anhydrous magnesium sulfate) and concentrated in vacuo to give, after purification by flash chromatography on silica gel, 2-tert-butoxycarbonylamino-3-(4-fluoro-phenylsulfanyl)-propionic acid methyl ester (2.28 g, 83%) as a yellow oil.
後処理
- stirringthe resulting mixture was stirred for two hours
- concentrationconcentrated in vacuo
- dissolutionThe residue was dissolved in ethyl acetate (100 ml)
- washwashed with water (2*80 ml) and brine
- dry with materialThe organic layer was dried (anhydrous magnesium sulfate)
- concentrationconcentrated in vacuo
- customto give
- customafter purification by flash chromatography on silica gel, 2-tert-butoxycarbonylamino-3-(4-fluoro-phenylsulfanyl)-propionic acid methyl ester (2.28 g, 83%) as a yellow oil
出典と根拠
- ORDレコード
- ord-b64c81fbdb9f4444baef37d83817bdde
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06632826B1
関連ノート
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