Nitric Acid → 1-Bromo-2,5-dimethyl-4-nitrobenzene

HRID 988933ノート

反応式

HRID 988933 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[N+:10]([O-])([OH:12])=[O:11].S(=O)(=O)(O)O>C(OC(=O)C)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][C:3]=1[CH3:9]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 11121Benzene, 2-bromo-1,4-dimethyl-

生成物 1

HCID 8258081-Bromo-2,5-dimethyl-4-nitrobenzene

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

740 g of bromo-p-xylene were initially introduced in acetic anhydride (ice-bath cooling) and nitrating acid (prepared from 400 ml of fuming nitric acid and 480 ml of concentrated sulfuric acid) was slowly added dropwise. During the addition, it was ensured that the internal temperature remained between 22° C.-25° C. When the addition was complete (duration about 5 hours), the ice bath was removed, and the mixture was stirred at RT for about a further 1 hour.

後処理

  1. additionwas slowly added dropwise
  2. additionDuring the addition, it
  3. customremained between 22° C.-25° C
  4. additionWhen the addition
  5. customthe ice bath was removed

出典と根拠

ORDレコード
ord-8b59aa4053fd431bafb677517bdcba32
出典データセット
uspto-grants-2003_10
特許番号
US06638646B2

反応ノート

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