Tetrahydrothiophene → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 988945

反応式

HRID 988945 の反応式
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10]>CC(C)=O>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 1127TetrahydrothiopheneHCID 21642Bromopinacolone

生成物 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide収率 85%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Using the 100-millilitter 3-port flask, 2 grams of tetrahydrothiophene was dissolved in 20 milli-litter of acetone. 4.87 grams of 1-bromo-3,3-dimethyl-2-butanone was dropped into the solution over agitation. After 24 hours, white crystal was precipitated, and was filtrated. The white crystal was pulverized, and was washed in ether. The pulverized white crystal was dried at 30 degrees in centigrade for 6 hours by using a low-pressure drier. 5.15 grams of 2-oxo-3,3-dimethylbutyl-thiacyclopentanium bromide was obtained. The yield was 75.0%.

後処理

  1. customwhite crystal was precipitated
  2. filtrationwas filtrated
  3. washwas washed in ether
  4. customThe pulverized white crystal was dried at 30 degrees in centigrade for 6 hours

出典と根拠

ORDレコード
ord-6edaecb22a8f4b71b53e7e8dd3d76215
出典データセット
uspto-grants-2003_10
特許番号
US06638685B2

関連ノート

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