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Chloroacetonitrile → 2-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetonitrile | HCID 7856 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Benzyl-2,5-diazabicyclo[2.2.1]heptane | HCID 562932 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane | HCID 21963645 | — |
反応手順
Finely ground potassium carbonate, as well as 1.3 mL of freshly distilled chloroacetonitrile were added to a solution of 3 g of 2-benzyl-2,5-diazabicyclo[2.2.1]heptane in 40 mL of anhydrous toluene and refluxed for 10 hours with vigorous stirring. The solution was cooled, filtered and evaporated. Bulb tube distillation (boiling point: 110°-120° C. at 0.01 mbar) resulted in 3.57 g of 140 as a colorless oil (97% of the theoretical yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06638925B2 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-b74a3b1c9a3f4525a31d3bb55d105ccf |
| 出典メモ | uspto-grants-2003_10 |