反应详情

Finely ground potassium carbonate, as well as 1.3 mL of freshly distilled chloroacetonitrile were added to a solution of 3 g of 2-benzyl-2,5-diazabicyclo[2.2.1]heptane in 40 mL of anhydrous toluene and refluxed for 10 hours with vigorous stirring. The solution was cooled, filtered and evaporated. Bulb tube distillation (boiling point: 110°-120° C. at 0.01 mbar) resulted in 3.57 g of 140 as a colorless oil (97% of the theoretical yield).

1. temperaturerefluxed for 10 hours with vigorous stirring
2. temperatureThe solution was cooled
3. filtrationfiltered
4. customevaporated
5. distillationBulb tube distillation (boiling point: 110°-120° C. at 0.01 mbar)