Hydrochloric Acid → 4-Chloro-6,7-dimethoxyquinoline-3-carboxylic acid

HRID 989055ノート

反応式

HRID 989055 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[Cl:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[O:5])C.[OH-].[Na+].Cl>C(O)C.O>[Cl:16][C:15]1[C:14]2[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([O:17][CH3:18])[CH:13]=2)[N:8]=[CH:7][C:6]=1[C:4]([OH:5])=[O:3]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 103571783-Carbethoxy-4-chloro-6,7-dimethoxylquinoline

生成物 1

HCID 180050224-Chloro-6,7-dimethoxyquinoline-3-carboxylic acid収率 116.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

4-chloro-6,7-dimethoxy-3-quinolinecarboxylic ethyl ester (ex RSL) (50 g) was suspended in ethanol (400 ml) and aqueous 2M sodium hydroxide (400 ml) was added with stirring, stirred for 24 hours. The reaction mixture was diluted with water (400 ml), cooled in an ice/water bath and brought to pH4 by carefully addition of concentrated hydrochloric acid. The resulting solid was filtered off, washed with water and dried in a vacuum oven at 50° C. To give 4-chloro-6,7-dimethoxy-3-quinolinecarboxylic acid (52.7 g, 98.7%).

後処理

  1. stirringstirred for 24 hours
  2. temperaturecooled in an ice/water bath
  3. filtrationThe resulting solid was filtered off
  4. washwashed with water
  5. customdried in a vacuum oven at 50° C

出典と根拠

ORDレコード
ord-88e97d518c1b403e8554a7da5a29042a
出典データセット
uspto-grants-2003_10
特許番号
US06638945B1

反応ノート

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