Tetrahydrofuran → HCID 18005526、化合物

HRID 989263ノート

反応式

HRID 989263 の反応式
C([Si](C)(C)O[C:7]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9](=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[CH:8]=1)(C)(C)C.C1C[O:27]CC1>>[CH3:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][C:9]1[C:8](=[O:27])[CH2:7][CH2:13][CH2:12][CH2:11][CH:10]=1

参加物

3

反応物 2

HCID 8028Tetrahydrofuran2 回HCID 69965728tert-Butyl(dimethyl){[3-(2-methylbenzylidene)-1-cyclohepten-1-yl]oxy}silane

生成物 1

HCID 18005526HCID 18005526、化合物

実験手順

A solution of n-tetra-n-butylammonium fluoride (1M) in THF (1.35 mmol) is added using a syringe to a solution of the compound obtained in Step A (1.34 mmol) in 15 ml of anhydrous THF at 0° C., and the whole is stirred at that temperature for 1 hour 30 minutes. The reaction mixture is then concentrated to dryness and deposited directly over a column of silica gel (heptane/AcOEt 9/1) to yield the title product.

後処理

  1. customat 0° C.
  2. concentrationThe reaction mixture is then concentrated to dryness

出典と根拠

ORDレコード
ord-8ab77105869e4e05b0462a40eb1a982f
出典データセット
uspto-grants-2003_10
特許番号
US06638962B2

反応ノート

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