Thionyl Chloride → 1-(4-Chloromethyl-benzyl)-pyrrolidine

HRID 989272ノート

反応式

HRID 989272 の反応式
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13]O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:17])=O>C(Cl)Cl>[Cl:17][CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 16495034{4-[(Pyrrolidin-1-yl)methyl]phenyl}methanol

生成物 1

HCID 164950351-(4-Chloromethyl-benzyl)-pyrrolidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the product of Step C in DCM (200 mL) was treated with thionyl chloride (20 mL) at 40° C. for 16 hours. Solvent was removed in vacuo to give the titled compound (15 g), which was used without purification.

後処理

  1. customSolvent was removed in vacuo

出典と根拠

ORDレコード
ord-c2fe768ad721481a83c81c09dfad51ef
出典データセット
uspto-grants-2003_10
特許番号
US06638967B2

反応ノート

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