Sodium Azide → 7-Azido-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile

HRID 989295ノート

反応式

HRID 989295 の反応式
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:16]=3[CH3:23])=[C:7]([C:12]#[N:13])[CH:8]=[N:9]2)=[CH:4][C:3]=1[N+:24]([O-:26])=[O:25].[N-:27]=[N+:28]=[N-:29].[Na+]>>[N:27]([C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:16]=3[CH3:23])=[C:7]([C:12]#[N:13])[CH:8]=[N:9]2)=[CH:4][C:3]=1[N+:24]([O-:26])=[O:25])=[N+:28]=[N-:29]

参加物

3

反応物 2

HCID 33557Sodium AzideHCID 219563857-Chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile

生成物 1

HCID 219564947-Azido-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile収率 91.1%

反応条件

温度
60 °C

実験手順

A mixture of 0.7 g (1.9 mmol) of 7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile and 0.62 g (9.5 mmol) of sodium azide is heated at 60° C. under nitrogen for 24 hours. The mixture is cooled and poured onto ice. The solid is collected by filtration, washed with water and dried to yield 0.65 g of 7-azido-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile as a yellow solid.

後処理

  1. temperatureThe mixture is cooled
  2. additionpoured onto ice
  3. filtrationThe solid is collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-553a6f915b814c169462cb93a715567a
出典データセット
uspto-grants-2003_10
特許番号
US06638929B2

反応ノート

読み込み中…