Sodium Carbonate → HCID 21956430、化合物

HRID 989298ノート

反応式

HRID 989298 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:15])=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]#[N:17].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:29][CH3:30])[C:26]=1[O:27][CH3:28])[NH2:23].Cl.N1C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>C(OCCO)C.O>[Cl:15][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:23][C:22]3[CH:24]=[C:25]([O:29][CH3:30])[C:26]([O:27][CH3:28])=[C:20]([O:19][CH3:18])[CH:21]=3)=[C:3]([C:16]#[N:17])[CH:4]=[N:5]2)=[CH:10][C:9]=1[N+:12]([O-:14])=[O:13]

参加物

7

反応物 4

HCID 10340Sodium CarbonateHCID 322853,4,5-TrimethoxyanilineHCID 10176127Pyridinium chlorideHCID 219564524,7-Dichloro-6-nitroquinoline-3-carbonitrile

生成物 1

HCID 21956430HCID 21956430、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8076Glycol monoethyl ether溶媒

反応条件

温度
105 °C

実験手順

A mixture of 500 mg (1.86 mmol) of 4,7-dichloro-6-nitro-3-quinolinecarbonitrile, 342.0 mg (1.86 mmol) of 3,4,5-trimethoxyaniline and 215.5 mg (1.86 mmol) of pyridine hydrochloride in 25 mL of 2-ethoxyethanol is heated at 100-110° C. for 1.5 hours. After cooling, the mixture is diluted with water and neutralized with an aqueous solution of saturated sodium carbonate. The solid is collected by filtration and is washed with water. After drying in vacuo, this yields 621.0 mg (80.5%) of the product as a deep yellow solid.

後処理

  1. temperatureAfter cooling
  2. filtrationThe solid is collected by filtration
  3. washis washed with water
  4. customAfter drying in vacuo

出典と根拠

ORDレコード
ord-7c117937bfc24df0a5a1f5b248aba7a8
出典データセット
uspto-grants-2003_10
特許番号
US06638929B2

反応ノート

読み込み中…