Benzoyl Peroxide → 2-(Bromomethyl)-6-fluoronaphthalene
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2.C1C(=O)N([Br:20])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:20][CH2:12][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[CH:8]=1参加物
5
実験手順
6-Fluoro-2-methylnaphthalene (20.5 g, 128 mmol, prepared by adaptation of the method of Wolinska-Mocydlarz et al2) and NBS (22.8 g, 128 mmol) were heated at reflux for 16 hr in CCl4 (210 mL) during which time, benzoyl peroxide (2.5 g) was added portionwise. The cooled solution was filtered and evaporated and the residue was extracted thoroughly with hexane (4×250 mL). The extracts were decanted from tarry material, combined and evaporated to give the product as a yellow solid, 29.8 g (97%).
後処理
- temperaturewere heated
- additionwas added portionwise
- filtrationThe cooled solution was filtered
- customevaporated
- extractionthe residue was extracted thoroughly with hexane (4×250 mL)
- customThe extracts were decanted from tarry material
- customevaporated
出典と根拠
- ORDレコード
- ord-5cd8038720464ff5a4fabe12d3de951b
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06458779B1
反応ノート
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