3-Nonanone → 3-Nonanol

HRID 989728

反応式

HRID 989728 の反応式
[CH3:1][CH2:2][C:3](=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[BH4-].[Na+]>CO>[CH3:1][CH2:2][CH:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 612353-NonanoneHCID 4311764Sodium borohydride

生成物 1

HCID 122163-Nonanol収率 96.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

20.5 g (144 mmol) of 3-nonanone are initially charged in 200 ml of methanol, 5.45 g (144 mmol) of sodium borohydride are added a little at a time at room temperature and the mixture is stirred overnight. The solvent is removed under reduced pressure and the mixture is then acidified and extracted with dichloromethane. The organic phase is dried over sodium sulphate. Removal of the solvent gives 20 g (96%) of a colourless oil.

後処理

  1. customThe solvent is removed under reduced pressure
  2. extractionextracted with dichloromethane
  3. dry with materialThe organic phase is dried over sodium sulphate
  4. customRemoval of the solvent

出典と根拠

ORDレコード
ord-f63b7042858a417da8139487ee5a4ea2
出典データセット
uspto-grants-2002_10
特許番号
US06458796B1

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