Ammonia methanol → 7-Sulfamoylimidazo[5,1-b]thiazole
反応式
[NH3:1].CO.Cl[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])=[O:6]>C1COCC1>[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])(=[O:6])[NH2:1]参加物
4
実験手順
A 2 M ammonia/methanol solution (4 ml) was added to a solution of 0.44 g of 7-chlorosulfonylimidazo[5,1-b]thiazole in 10 ml of THF. The mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1) to give 0.34 g of 7-sulfamoylimidazo[5,1-b]thiazole.
後処理
- concentrationThe reaction mixture was concentrated
- customThe residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1)
出典と根拠
- ORDレコード
- ord-68e035aa4b924d19b3ebc853d3385982
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06458780B1
反応ノート
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