Hydrochloric Acid → HCID 11220404、化合物

HRID 989898ノート

反応式

HRID 989898 の反応式
C[O:2][C:3]([C:5]1[N:6]=[C:7]([CH2:10][CH:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:8][CH:9]=1)=[O:4].[Li+].[I-].Cl>N1C=CC=CC=1>[C:3]([C:5]1[N:6]=[C:7]([CH2:10][CH:11]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:8][CH:9]=1)([OH:4])=[O:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 66321Lithium iodideHCID 23389069Ethyl (+/-)-4-(4-methoxycarbonyl-1,3-oxazol-2-yl)-3-phenylbutanoate

生成物 1

HCID 11220404HCID 11220404、化合物収率 80.5%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of ethyl (±)-4-(4-methoxycarbonyl-1,3-oxazol-2-yl)-3-phenylbutanoate (267 mg, 0.84 mmole) and LiI (338 mg, 2.52 mmole) in pyridine (5 mL) was heated to reflux. After 18 hr, the mixture was cooled to RT, poured into 10% HCl (150 mL), then extracted with CH2Cl2 (3×50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated to give the title compound (205 mg, 80%) as a white solid: MS (ES) m/e 304 (M+H)+.

後処理

  1. extractionextracted with CH2Cl2 (3×50 mL)
  2. dry with materialThe combined organic extracts were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-5588958b415d4be39f7d8d9071022f4e
出典データセット
uspto-grants-2002_10
特許番号
US06458814B1

反応ノート

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