HCID 2800136、化合物 → 6-(4-chloro-2-methylphenoxy)pyridin-3-amine

HRID 990180ノート

反応式

HRID 990180 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=2)=[C:4]([CH3:18])[CH:3]=1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][N:8]=2)=[C:4]([CH3:18])[CH:3]=1

参加物

5

反応物 2

HCID 2800136HCID 2800136、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 28001436-(4-chloro-2-methylphenoxy)pyridin-3-amine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

2-(4-chloro-2-methyl-phenoxy)-5-nitropyridine (203 mg, 0.77 mmol) was dissolved in 95% ethanol (3 mL) and treated with 20% palladium hydroxide on carbon (50 mg). The reaction mixture was shaken in a hydrogen atmosphere (40 psi) for 1 hour. The solution was filtered through celite and concentrated in vacuo . MS (m/z): 234/236 (M+H)+; C12H11N2OCl requires 234.7.

後処理

  1. filtrationThe solution was filtered through celite and
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3429fb8f04d740daa2e80dde4329c090
出典データセット
uspto-grants-2002_10
特許番号
US06458813B1

反応ノート

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