HCID 3529665、化合物 → HCID 15887620、化合物

HRID 990187ノート

反応式

HRID 990187 の反応式
[CH:1]1([N:7]([CH3:17])[C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[OH-].[OH-].[Pd+2]>[CH:1]1([N:7]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][N:9]=2)[CH3:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

4

反応物 1

HCID 3529665HCID 3529665、化合物

生成物 1

HCID 15887620HCID 15887620、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

Cyclohexyl-methyl-(5-nitro-pyridin-2-yl)-amine (1.72 g, 7.3 mmol) was dissolved in ethanol (80 mL) and treated with 20% palladium hydroxide on carbon (Pearlman's catalyst, 0.5 g) and the mixture was shaken under a hydrogen atmosphere (50 psi) for 6 hours. The catalyst was removed by filtration through celite then the filtrate was concentrated in vacuo and the resultant oil was chromotographed on SiO2 using 1:1 ethyl acetate/hexanes as eluent. MS (m/z): 206 (M+H)+; C12H19N3 requires 205.3.

後処理

  1. customThe catalyst was removed by filtration through celite
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-4ff9338535b9445fab75f5930741ecb2
出典データセット
uspto-grants-2002_10
特許番号
US06458813B1

反応ノート

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