Hydrochloric Acid → 3-(3-Methoxyphenyl)-1,4-dihydroindeno[1,2-c]pyrazole

HRID 990972

反応式

HRID 990972 の反応式
C([Li])CCC.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[C:11](OCC)=O.Cl.[C:20]1(=[N:29][NH2:30])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21]1>O1CCCC1.CCCCCC>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([C:11]2[C:21]3[CH2:22][C:23]4[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:20]=3[NH:29][N:30]=2)[CH:16]=[CH:17][CH:18]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 66299Benzoic acid, 3-methoxy-, ethyl esterHCID 290932Indan-1-one hydrazoneHCID 178418339Butyllithium

生成物 1

HCID 120438253-(3-Methoxyphenyl)-1,4-dihydroindeno[1,2-c]pyrazole

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8058Hexane溶媒

実験手順

In a similar manner to Example 1, indan-1-one hydrazone (3.55 g) was dissolved in tetrahydrofuran (80 ml) at 0° C. under nitrogen with stirring. n-Butyllithium (28.8 ml of a 2.5M solution in hexane) was added to the solution and the mixture was stirred at 0° C. for 0.5 h. Ethyl 3-methoxybenzoate (2.16 g) was added, followed by 3M hydrochloric acid (80 ml) and the mixture was worked up as described in Example 1 to give 3-(3-methoxyphenyl)-1,4-dihydroindeno[1,2-c]pyrazole, m.p. 172-174° C.

後処理

  1. stirringthe mixture was stirred at 0° C. for 0.5 h

出典と根拠

ORDレコード
ord-a392912e7ad0428eab110df0b5844d1e
出典データセット
uspto-grants-2002_10
特許番号
US06462036B1

関連ノート

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