Hydrazine hydrate (1:1) → 4-(1,4-Dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
反応式
O=[C:2]1[C:10]2([CH:12]([C:13]3[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=3)O2)[CH2:9][C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.O.[NH2:23][NH2:24]>C(O)(=O)C.CO>[NH:23]1[C:2]2[C:3]3[C:8]([CH2:9][C:10]=2[C:12]([C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)=[N:24]1)=[CH:7][CH:6]=[CH:5][CH:4]=3参加物
5
実験手順
4-(1-Oxospiro[indan-2,2′-oxiran]-3′-yl)benzoic acid from Example 7b (780 mg), methanol (50 ml), hydrazine hydrate (0.18 ml) and glacial acetic acid (6 drops) were boiled under reflux for 24 hours. The mixture was cooled in ice and filtered to give 4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid, m.p. >320° C.
後処理
- temperatureunder reflux for 24 hours
- temperatureThe mixture was cooled in ice
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-0bdea34b53e84a23825daca7849a9092
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06462036B1
反応ノート
読み込み中…