Methyl Ethyl Ketone → Methyl-5-norbornene-2-carboxylic acid

HRID 991019

反応式

HRID 991019 の反応式
[CH3:1][C:2]1[CH2:6][CH:5]=[CH:4][CH:3]=1.[C:7]([OH:11])(=[O:10])C=C.[CH2:12](C(C)=O)[CH3:13]>>[CH3:1][C:2]12[CH2:6][CH:5]([CH:12]=[CH:13]1)[CH2:4][CH:3]2[C:7]([OH:11])=[O:10]

参加物

4

反応物 3

HCID 6569Methyl Ethyl KetoneHCID 6581Acrylic AcidHCID 667751-Methyl-1,3-cyclopentadiene

生成物 1

HCID 18417281Methyl-5-norbornene-2-carboxylic acid

実験手順

Methylcyclopentadiene (8.01 g: 100 mmol) was dissolved in methyl ethyl ketone (10 mL), to which acrylic acid (7.93 g: 110 mmol) was added dropwise at 0° C. over 1 hour. The thus-obtained mixture was stirred at room temperature for 3 hours. Light components, such as the solvent and unreacted acrylic acid, were then distilled off under reduced pressure from the reaction mixture, whereby methyl-5-norbornene-2-carboxylic acid (14.9 g: 98 mmol) was obtained.

後処理

  1. additionwas added dropwise at 0° C. over 1 hour
  2. distillationLight components, such as the solvent and unreacted acrylic acid, were then distilled off under reduced pressure from the reaction mixture

出典と根拠

ORDレコード
ord-5ca62e95097e4bfab6ef6fddcc2ae1a2
出典データセット
uspto-grants-2002_10
特許番号
US06462158B1

関連ノート

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