Hydrochloric Acid → HCID 9931407、化合物

HRID 991427ノート

反応式

HRID 991427 の反応式
P(Cl)(Cl)(Cl)=O.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11]([OH:13])=O.[NH2:19][C:20]1[CH:21]=[C:22]([NH:27][C:28](=[O:35])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[CH:24][C:25]=1[Cl:26].Cl>N1C=CC=CC=1>[C:28]([NH:27][C:22]1[CH:23]=[CH:24][C:25]([Cl:26])=[C:20]([NH:19][C:11](=[O:13])[C:10]2[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:8]([O:7][CH3:6])[CH:9]=2)[CH:21]=1)(=[O:35])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7121Veratric AcidHCID 24813Phosphorus oxychlorideHCID 16774920N-(3-Amino-4-chlorophenyl)benzamide

生成物 1

HCID 9931407HCID 9931407、化合物収率 52.8%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
0 °C

実験手順

Phosphoryl chloride (0.074 g) was added to a stirred mixture of 3,4-dimethoxybenzoic acid (0.088 g), N-(3-amino-4-chlorophenyl)benzamide (0.1 g) and pyridine (1 ml) which had been cooled to 0° C. The mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The mixture was poured into 1N aqueous hydrochloric acid solution and the resultant solid was isolated, washed with a saturated aqueous sodium bicarbonate solution and dried under vacuum at 55° C. There was thus obtained the title compound (0.088 g);

後処理

  1. temperatureto warm to ambient temperature
  2. customthe resultant solid was isolated
  3. washwashed with a saturated aqueous sodium bicarbonate solution
  4. customdried under vacuum at 55° C

出典と根拠

ORDレコード
ord-2ac77d2e7b0442e39f4501471b6d40e6
出典データセット
uspto-grants-2002_10
特許番号
US06465455B1

反応ノート

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